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Dr. Bob Marshall




DHLA: The Spectacular Antioxidant

DHLA (dihydrolipoic acid) is unique as an antioxidant due to its spectacular effectiveness in quenching every known free radical that occurs in living tissue, including both fat and water soluble tissues.  No other antioxidant has this incredible capability.  DHLA is readily absorbed orally and has very low toxicity.  It has unequalled potential as a highly effective therapeutic agent in clinical conditions associated with free radical damage such as Parkinson's disease, Alzheimer's disease and other neurodegenerative illnesses. (1)

Until 2003, DHLA in a stabilized form was not available.  DHLA could only be obtained indirectly through consuming ALA (alpha lipoic acid) which in turn, was converted by the body into small amounts of DHLA.  However, this process did not deliver a significant or reliable supply of DHLA.  Research studies have attempted to measure the effect of DHLA on cellular tissue using indirect methods based on ALA consumption.  As a result, DHLA is known to be a powerful electron donor to other compounds.  Ascorbic acid and indirectly vitamin E are regenerated by DHLA. (2)  Busse et. al. found that the oxidized form of DHLA, ALA, increased intracellular glutathione. (3)  DHLA was shown to regenerate coenzyme QIO, glutathione and NADPH or NADH and by this mechanism, increase cellular ATP production.(4)  The oxidized form of DHLA, ALA, also assists in the conversion of pyruvate to acetyl-coenzyme A, the beginning point of the Krebs cycle which produces the high energy molecule ATP.


Radical Synthetic vs. "Once Living" Sources

ALA, R-lipoic acid or DHLA that are derived from synthetic sources can never match natural source counterparts in the ability to sustain and repair the DNA of the cell.  A natural ("once living") source is comprised of dynamic, complex processes where each molecule contains atoms that generate photons, or in other words, pure light.  The photonic field around each molecule creates a "body of light" which surrounds all living substances.  Only nutrients derived from a "once living" source are capable of upgrading cellular DNA, according to quantum physics researcher and expert, Dr. Fritz-Albert Popp. (33)

On the other hand, synthetic source nutrients may provide initial cellular benefits, but over time, they act to accelerate the degeneration of DNA, ending in earlier cell death.  Synthetic nutrients initially stimulate the cell to accomplish work which may appear to be beneficial, but long-term, the DNA and cellular degradation cannot justify the initial benefits.  Consequently, using ALA derived from a synthetic source can defeat the purpose of using an ALA supplement to live longer more healthfully.  Not only has a stable form of DHLA been badly needed, but also a DHLA source that has been derived from a "once living" source so it is capable of imparting significant, long-term DNA protection and cellular benefits.


Benefits of Alpha Lipoic Acid

Many research studies show the spectacular benefits from the use of ALA, even ALA derived from synthetic sources.  Although these studies demonstrate many, short-term benefits of synthetic ALA, they do not test for or warn against the long-term problems encountered in consuming synthetically derived agents.

Unfortunately, most research studies using ALA have used the synthetic form which contains equal amounts of the R and the S racemic forms. The S form occurs only in synthetic source ALA, never in naturally-derived ALA, and has negative, pro-inflammatory effects.  In an attempt to enhance the effectiveness of synthetic ALA, some manufacturers have chemically removed the S-form, thus producing a new form, stand alone R-lipoic acid.  Because synthetically derived ALA contains both R and S forms, studies show that synthetic R-lipoic acid alone is superior to ALA (which contains both R and S forms).  A 1995 research study using DL-alpha-lipoic acid, a synthetic form containing both the R and the S forms in equal proportions, claimed that the resultant DHLA was both an antioxidant and a pro-oxidant where hydroxyl radicals were generated. (8)  However, new research since the year 2000 has shown the S-form of lipoic acid (which has pro-inflammatory effects) may well be the cause of this pro-oxidant study finding (rather than as an effect of DHLA).


Scavenger of Free Radicals

Lester Packer, PhD, of the University of California at Berkeley, has shown that ALA is a powerful free radical quencher and metal chelating agent. It helps regenerate other antioxidants and favorably affects gene expression. (1)  Experts are in general agreement that ALA can scavenge the hydroxyl radical, hypochlorous acid radical, and singlet oxygen radical, but not the peroxyl or superoxide anion free radical. (1, 5-7)


Arsenic Protection

Research has shown that ALA can protect mice from poisoning by sodium arsenite, an arsenical herbicide, insecticide and rodenticide by a ratio of ALA to arsenite of at least 8:1.  The mice were protected even if the administration of ALA was given after onset of severe symptoms of poisoning. (9)


Mercury Protection

Further research has demonstrated that ALA removed mercury from renal slices (kidney). (14)  ALA was also shown to dramatically increase biliary excretion of injected mercury while decreasing cadmium, zinc, copper and methylmercury excretion. (15)


Cadmium Protection

In another study, ALA and R-lipoic acid were shown more effective than S-lipoic acid (which occurs only in synthetic ALA) in metal chelation. (10)  In isolated hepatocytes (liver cells), ALA reduced cadmium induced toxicity.  However, DHLA was much more effective than ALA. (11)  ALA (and therefore DHLA at least as much or more) was shown to provide significant liver protection against cadmium toxicity, even under glutathione depleted experimental conditions. (12)  Another study showed ALA completely prevented cadmium induced lipid peroxidation in the brain, heart and testicles in rats. (13)


Restoration of Metabolism and Mobility

R-lipoic acid supplementation reversed the age related, declining ability of rats to respond to increased oxidative stress.  The age decline was almost completely reversed on a two week dietary supplementation of R-lipoic acid. (16)  When fed to old rats, R-lipoic acid showed complete reversal of declining levels of glutathione and ascorbic acid in hepatocytes.  In addition, the metabolic rate and mobility of the old rats were also restored to that of youthful rats. (17,18)


Improvement in Type II Diabetes

Since the year 2000, about 80% of all type II diabetes is now believed to be linked to infection.  Type II diabetes is now at epidemic proportions with 900,000 new cases per year in the U.S.  The infectious process produces large amounts of free radicals.  One marker of free radical damage common to Type II diabetes is AGEs (advanced glycation end products).  Glycation of protein can be caused by elevated blood and tissue glucose.  Packer and Kawabata (20) showed that noncovalent binding of ALA to albumin protects protein from glycation.

Other studies using ALA in Type II diabetes have shown improvement in insulin metabolism. (21,22)  Nerve damage (polyneuropathies) is common in diabetes and has been successfully treated with ALA in Germany for more than 20 years.  Findings show that ALA administration yielded excellent results: albuminuria decreased 50%, (23) and neuropeptide deficits, nerve blood flow and neurological symptoms all improved. (24,25,26)


Glaucoma Improvement

In one glaucoma study, stage I and IIOAG (open-angle glaucoma) patients were assigned to one of 3 groups:  no ALA, 75 mg or 150 mg ALA daily for 2 months.  The greatest improvement in visual function, efficacy of liquid discharge and biochemical markers were observed in the group receiving the higher dose of ALA. (30)


Benefits of Stabilized DHLA

The above clinical research studies using synthetically-derived ALA had obviously spectacular physiological benefits. However, as has been emphasized earlier, these benefits are not without a price to pay, namely, the eventual degradation of the cellular DNA which occurs during long-term use of synthetic compounds.

Advantages of Natural-Source DHLA

Stabilized DHLA (natural-source) may prove to be one of the most significant antioxidant compounds ever created, since it can accomplish all the feats attributed to ALA and more, but without ALA's negative effects. In fact, some authors believe that the benefits ascribed to ALA are in fact, actually due to the internal generation of DHLA (after ALA consumption). For the very first time, stabilized DHLA is now available that can offer significant and reliable amounts of DHLA, without the need to consume synthetic precursors.


DNA and Nerve Protection

Stabilized DHLA can provide exquisite neuroprotection as well as superior DNA protection and repair, unmatchable by any other antioxidant. Studies show that DHLA increases cellular energy and efficiency by increasing ATP. At the same time, DHLA helps regenerate the production of vitamin E, CoQIO, glutathione, NADH and NADPH to provide unparalleled DNA protection. In addition, DHLA has the capacity to induce repair of DNA strand breaks.7 For long-term benefits of DHLA, only natural-source DHLA is recommended to avoid the long-term degradation of DNA from synthetically-derived sources.


Arterial and Heart Protection

Research has shown that DHLA can accelerate recovery of the aortic blood flow during reperfusion (resumption of blood flow) and increase ATP synthesis in the rat heart.27 ALA forms were not helpful only internally generated DHLA was able to reduce the infarct or necrotic tissue size in middle cerebral artery occlusion in mice.28 Wolz et. al. believe ALA must be reduced to the DHLA form in order to provide neuroprotection.29 Natural-source, stabilized DHLA (now available) can provide exquisite neuroprotection as well as superior DNA repair and protection without compromise.


DHLA: Safety and Effectiveness

Clinical research by Dr. Robert J. Marshall has shown that the newly available natural-source, stabilized DHLA is both safe and effective for general use, including those with chronic illness and neurodegenerative disease. If high dosages (over 300 mg/day) of stabilized DHLA are used, to get maximum benefits the concurrent use of additional nutrients such as nutritional yeast which contains natural-source B vitamins, sulphur-based amino acids and reduced glutathione, is an excellent adjunct.


Brief Clinical Observations

The discoverer and inventor of stabilized DHLA, Dr. Marshall, has observed various immediate, spectacular effects of oral administration of stabilized DHLA in his office.

One 44-year woman presented with a history of bilateral, maxillary sinus infection with extreme pain even to the touch. She had used oral antiobiotics for more than a year with no relief and was unable to breathe through her sinuses for at least 10 months. Further, she had begun to experience pain at her liver, chronic fatigue, loose stool and severe brain fog. After only one dose (30 drops) of natural-source, stabilized DHLA, within less than one minute, she remarked, "I can breathe through my nose! My head feels clear for the first time in 10 months."

A 60 year-old male complaining of brain fog, diminished short-term memory and a general sense of malaise remarked that within one day of taking natural-source, stablilized DHLA, literally all his symptoms were gone. He had a renewed sense of mental acuity and a significant improvement in short-term memory.

A medical doctor has remarked that in many clinical cases, natural-source, stabilized DHLA reduced the amount of time and number of nutritional supplements needed to restore healthy nerve function in his patients. It has become one of his most used supplement "aces", especially in neurodegenerative cases.


References

1. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as biological antioxidant. Free RadBiolMed 1995;19:227-250.

2. Scholich H, Murphy ME, Sies H. Antioxidant activity of dihydrolipoatc against microsomal lipid peroxidation and its dependence on a-locophcro}. Biochem Biophys Acta 1989; 1001:256-261.

3. Busse E, Zimmer G, Schopohl B, etal. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittel-Forschung 1992:42:829-831.

4. Kagan v, Serbinova E, Parker L. Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by locopherol recycling. Biochem Biophys Res Comm 1990; 169:85 1-857.

5. Passwaier RA. Lipoic Acid: The Metabolic Antioxidant. New Canaan, CT: Keats Publishing, Inc; 1995: 1-47.

6. Scott BC, Arouma OI, Evans PJ, et al. Lipoic and dihydrolipoic acid as antioxidants: a critical evaluation. Free Rad Res 1994;20;119-133.

7. Suzuki Yj, Tsuchiya M, Packer L. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad Res Comms 1991; 15:255-263.

8. Sandhya P, Mohandass S, Varalakshnii P. Role of DL alpha-lipoic acid in genlamicin induced nephrotoxicity. Mot CellBiochem 1995;145:11-17.

9. MGrunert RR. The effect of DL Alpha-lipoic acid on heavy-metal intoxication in mice and dogs. Arch Biochem Biophys 1960;86: 190-194.

10. Ou P, Tritschler Hj, Wolff SP. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant. Biochem Pharmacol 1995;50:123-126.

11. MullerL, Menzel H. Studies on the efficacy of lipoate and dihydrolipoate in the alteration of cadmium toxicity in isolated hepatocyles. Biochem Biophys Acta 1990; 10523 :386-39 1 .

12. Sumathi R, Baskaran G, Varalakshmi P. Relationship between glutathione and DL alpha-lipoic acid against cadmium-induced hepatoloxicity. Jpn 3 Med Sci Biol 1996;49:39-48.

13. Sumathi R, Devi VK, Varalakshmi P. DL alpha-lipoic acid protection against cadmium-induced tissue lipid peroxidation. Med Sci Res 1994:22:23-25.

14. Keith RL, Sctiarahardjo I, Fernando Q, et al. Utilization of renal slices to evaluate the efficacy of chelating agents for removing mercury from the kidney. Toxicology 1997;116:67-75.

15. Gregus Z, Stein AF, Varga F. Effect of lipoic acid on biliary excretion of glutathione and metals. ToxicolAppl Pharmacol 1992;114:88-96.

16. Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes reversal with (R)-alpha-lipoic acid supplementation. FASEB J 1998 Sep;12(12):1183-9.

17. Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wchr CM, Vinarsky V, Bartholomew JC, Ames AB. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J 1999 Feb;l3(2):41 1-8.

18. Hagen TM, Vinarsky V, Wehr CM. Ames BN. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal 2000 Fall;2{3):473-83.

19. Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J 2001 Mar; 15(3):700-6.

20. Kawabata T, Packer L. Alpha-lipoale can protect against glycation of serum albumin, but not low density lipoprotein. Biochem Biophys Res Comms 1994;203:99-104.

21. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittel-Forschung 1995;45:872-874.

22. Jacob S. Henriksen EJ, Tritschler HJ, el al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabetes 1996; 104:284-288.

23. Kchler W, Kuklinski B, Ruhlmann C, Plotz C. Diabetes mellitus-a free radical associated disease: Effects of adjuvant supplementation of antioxidants. In: Gries FA, Wessel K, eds. The role of antioxidants in diabetes mellitus: Oxygen radicals and antioxidants in diabetes. Frankfurt am Maine: pmi. Verl-Gruppe', 1993: 33-35.

24. Garrett NE, Malcangio M, Dewhurst M, Tomlinson DR. Alpha-lipoic acid corrects neuropeptide deficits in diabetic rats via induction of trophic support. Neurosct Lett 1997;222:191-194.

25. Nagamatsu M, Nickander KK, Schmelzer JD. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetic Care 1995; 18: 1160-1 166.

26. Ziegler D, Hanefield M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the anli-oxidant alpha-lipoic acid. A 3-week mullicenter randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-1433.

27. Assadnazari H, Zimmer G Freisleben HJ, et al. Cardioprotective efficiency of dihydrolipoic acid in working rat hearts during hypoxia and reoxygcnation. P nuclear magnetic resonance investigations. Arzneimittel-Forschung 1993:43:425-432.

28. Prehn JH, Karkoutly C, Nuglisch J, et al. Dihydrolipoale reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12:78-87.

29. Wolz P, Krieglstein J. Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia. Nettropharmacology 1996:35:369-375.

30. Filina AA, Davydova NG, Endrikhovskii SN, et al. Lipoic Acid as a means of metabolic therapy of open-angle glaucoma. Vestn Oftalmol 1995;lll:6-8.

31. Ou P, Nourooz-Zadeh J, Tritschler HJ, Wolff SP. Activation of aldose reductase in rat lens and metal-ion chelation by aldose reductase inhibitors and lipoic acid. Free Radic Res 1996;25:337-346.

32. Maitra I, Serbinova E, Tritschler HJ, Packer L. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Free Radic Biol Med 1995;l8:823-829.

33. Durr HP, Popp FA, Schommers W, eds. What Is Life: Scientific Approaches and Philophical Positions. World Scientific CO USA River Edge NJ 2002:307-328




* These statements have not been evaluated by the Food and Drug Administration.  This health product is not intended to diagnose, treat, cure or prevent disease.  Health Products USA recommends consulting a physician before taking any health supplements.

 


Founder of Quantum Nutrition Labs, Dr. Robert Marshall is a certified, internationally trained clinical nutritionist, past president of the International and American Association of Clinical Nutritionists, member of the American Society of Tropical Medicine and Hygiene. He is the host of HealthLine, a radio broadcast aired continuously since 1986, currently in over 15 states, and the author of many research papers and articles. Dr. Marshall has operated one of the largest chronic illness practices in Southern California for many years. Currently his main activities include overseeing Quantum Nutrition Labs' manufacturing, as well as writing and teaching professional seminars.

Dr. Bob Marshall maintains clinical facilities in Torrance, California and Round Rock, Texas, where he continues to test and refine new and existing formulations. Quantum Nutrition Labs provides consumers and health professionals with full lines of nutritional, body care, and lifestyle products that work synergistically to achieve and keep great health. Quantum Nutrition Labs has clinically developed its products, working together with medical doctors, chiropractors, nutritionists and other health professionals to produce functional food/herb phytonutrient products that embody "Nutrition That Really Works". Dr Marshall delivers uncompromising quality using unwavering standards of excellence to ensure extraordinary product purity. He has developed, clinically tested and proven the effectiveness of each of its cutting edge nutritional formulas. Dr. Marshall's mission is: "to empower every person to access their own limitless healing potential through the use of HealthLine resonance nutraceutical formulations, spectacular detoxification techniques and premier therapeutic strategies."

Health Products USA is licensed to distribute nutritional products manufactured by Quantum Nutrition Labs - Austin, TX